Lysosomes: Regulators of autophagy in the retinal pigmented epithelium
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- 作者：Debasish Sinhaa ; Debasish@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Mallika Valapalaa ; Peng Shanga ; b ; Stacey Hosea ; Rhonda Grebea ; Gerard A. Luttya ; J. Samuel Zigler Jr.a ; Kai Kaarnirantac ; James T. Handaa
- 关键词：AMD ; Autophagy ; βA3/A1-crystallin ; Lysosome ; mTORC1 ; Oxidative stress ; RPE ; V-ATPase
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：144
- 期：Complete
- 页码：46-53
- 全文大小：2292 K
文摘
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In the RPE, lysosomes modulate both heterophagy and autophagy to maintain retinal homeostasis.
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The mTORC1 signaling pathway regulates the biogenesis, distribution and activity of lysosomes.
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βA3/A1-crystallin is a novel target for restoring normal lysosome function in human AMD disease.