文摘
An aggravated EAE was observed in HFD-induced obese mice compared with ND-mice. Significantly upregulated genes in EAE were related to immune response, antigen presentation, complement activation, etc. C4b, Psmb8, Ly86, Ms4a6d, Cul9, and Mast2 are novel genes upregulated in both ND- and HFD-EAE mice. Cul9 and Mast2 genes of metal ion-binding proteins were upregulated in HFD-EAE mice than in ND-EAE mice.