Thromboangiitis obliterans with multiple large vessel involvement: case report and analysis of immunophenotypes

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• 作者：Naoki Edo ; Kosuke Miyai ; Sho Ogata ; Kuniaki Nakanishi ; Sadayuki Hiroi ; Susumu Tominaga ; Satoshi Aiko ; Toshiaki Kawai
• 关键词：Thromboangiitis obliterans ; Intestinal Buerger's disease ; Immunophenotype
• 刊名：Cardiovascular Pathology
• 出版年：2010
• 出版时间：January-February 2010
• 年：2010
• 卷：19
• 期：1
• 页码：59-62
• 全文大小：585 K

文摘

Abstract

Thromboangiitis obliterans (TAO, Buerger's disease) is an idiopathic, recurrent, segmental, nonatherosclerotic, inflammatory, occlusive vascular disease with a poorly understood pathogenesis. Intestinal or multi-organ involvement is rare. Recent immunohistochemical analyses of ordinary TAO have indicated an inflammatory and immunologic pathogenesis. We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3(+) T cells were revealed around the recanalization sites within the abdominal aorta. CD4(+) T cells were almost equal in number to CD8(+) T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO).