刊名:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
出版年:2017
出版时间:January 2017
年:2017
卷:1863
期:1
页码:165-173
全文大小:1348 K
卷排序:1863
文摘
The ataxia related G1107D mutation of the PMCA 3 impairs its calcium pumping function The mutation affects the interplay of calmodulin with its binding domain on the pump, decreasing its stimulation. The auto inhibitory ability of the calmodulin-binding domain in the resting state is also affected Dissection of the molecular detail of the defect suggests a dual negative effect on the function of the pump