Effects of chitosan on rat knee cartilages
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- 作者：Xi Lu ; Jian ; Prudhommeaux ; Florence ; Meunier ; Alain ; Sedel ; Laurent ; Guillemin ; Geneviè ; ve
- 关键词：Chitosan ; Epiphyseal cartilage ; Articular cartilage ; Chondrocytes ; Rat knee joint
- 刊名：Biomaterials
- 出版年：1999
- 出版时间：October, 1999
- 年：1999
- 卷：20
- 期：20
- 页码：1937-1944
- 全文大小：772 K
文摘
The aim of this work is to study the effects of chitosan on rat knee cartilages. 0.2 ml of 0.1 % chitosan solution pH=6.9 were injected inside rat knees articular cavity. One, three and six weeks after injection, histological and histomorphometric studies were performed on undecalcified samples embedded in polymethylmetacrylate. Results show that after 1 and 6 weeks: (i) chitosan slows significantly (P<0.005) the decrease in epiphyseal cartilage thicknesses and (ii) increases significantly articular cartilage chondrocyte densities (P<0.002). However chitosan solution induces a proliferation of fibrous tissue with abundant fibroblasts, fibrocytes and monocytes inside the joint and this proliferation is still present after 6 weeks. This study suggests that chitosan could act on the growth of epiphyseal cartilage and wound healing of articular cartilage.