Tunable temperature responsive liquid chromatography through thiolactone-based immobilization of poly(N-isopropylacrylamide)
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- 作者：Angel J. Satti
- 关键词：HPLC ; Thiol-ene conjugation ; Thiolactone ; Poly(N-isopropylacrylamide) ; Purely aqueous
- 刊名：Journal of Chromatography A
- 出版年：2015
- 出版时间：24 December 2015
- 年：2015
- 卷：1426
- 期：Complete
- 页码：126-132
- 全文大小：1775 K
文摘
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Thiolactone-based ring opening is proposed for immobilization of stationary phases.
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The strategy allows immobilization of temperature responsive phases.
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Higher hydrophobic retention and even diastereoisomeric separation are obtained.
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Two types of polymers can be immobilized on aminopropyl function in this way.
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HPLC stationary phases can be fine-tuned in this way.