CC bond formation using ThDP-dependent lyases

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• 作者：Michael Mü ; ller¹ ; ^{michael.mueller@pharmazie.uni-freiburg.de} ; Georg A Sprenger² ; Martina Pohl³
• 刊名：Current Opinion in Chemical Biology
• 出版年：2013
• 出版时间：April, 2013
• 年：2013
• 卷：17
• 期：2
• 页码：261-270
• 全文大小：474 K

文摘

The present review summarizes recent achievements in enzymatic thiamine catalysis during the past three years. With well-established enzymes such as BAL, PDC and TK new reactions have been identified and respective variants were prepared, which enable access to stereoisomeric products. Further we highlight recent progress with ¡®new¡¯ ThDP-dependent enzymes like MenD and PigD, which catalyze the Stetter-like 1,4 addition of aldehydes and YerE, which is the first known ThDP-dependent enzyme accepting ketones as acceptors.