Toxocara canis: Larvicidal activity of fatty acid amides

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• 作者：Taí ; s Mata-Santos^a ; ^{farmatais@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Caroline da Ros Montes D&rsquo ; Oca^b ; Hí ; lton Antô ; nio Mata-Santos^c ; Juliana Fenalti^a ; Nitza Pinto^a ; Tatiane Coelho^d ; Maria Elisabeth Berne^e ; Pedro Eduardo Almeida da Silva^d ; Marcelo Gonç ; alves Montes D&rsquo ; Oca^b ; ^&dagger ; ; Carlos James Scaini^a ; ^&dagger ;
• 关键词：Toxocarosis ; Chemotherapy ; Cytotoxicity ; Chemical compounds
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：1 February 2016
• 年：2016
• 卷：26
• 期：3
• 页码：739-741
• 全文大小：369 K

文摘

Considering the therapeutic potential of fatty acid amides, the present study aimed to evaluate their in vitro activity against Toxocara canis larvae and their cytotoxicity for the first time. Linoleylpyrrolidilamide was the most potent, with a minimal larvicidal concentration (MLC) of 0.05 mg/mL and 27% cytotoxicity against murine peritoneal macrophages C57BL/6 mice, as assessed by the MTT assay.