Evaluating the interaction between di-fluorinated chalcones and plasmatic albumin
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- 作者：Leonardo Santos de Barrosa ; Otá ; vio Augusto Chavesa ; Edgar Schaeffera ; Carlos Mauricio R. Sant&rsquo ; Annaa ; Auré ; lio B.B. Ferreiraa ; Dari Cesarin-Sobrinhoa ; Francisco Assis da Silvaa ; José ; Carlos Netto-Ferreiraa ; b ; jcnetto.ufrrj@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fluorinated chalcones ; Bovine serum albumin ; Fluorescence ; Circular dichroism ; Molecular docking
- 刊名：Journal of Fluorine Chemistry
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：190
- 期：Complete
- 页码：81-88
- 全文大小：2603 K
文摘
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The ligand-binding studies were performed by spectroscopy and molecular docking.
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The samples follow combination of static and dynamic fluorescence quenching mechanism.
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The Ka values indicate a moderate interaction between the ligands and albumin.
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Hydrogen bonding and hydrophobic interactions are the main binding forces.
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Changing the fluorine atoms position did not change the binding ability.