Linking genomic responses of gonads with reproductive impairment in marine medaka (Oryzias melastigma) exposed chronically to the chemopreventive and antifouling agent, 3,3′-diindolylmethane (DIM)
Marine medaka were exposed chronically to low-doses of DIM. Toxicogenomic responses of gonads were profiled at transcript and protein levels. Molecular initiating events were linked to adverse apical outcomes. VTG mobilization was blocked by lower abundance of cathepsin enzyme in ovary. Eggshell proteins were more indicative of reproductive failure than VTG.