Does medial temporal lobe thickness mediate the association between risk factor burden and memory performance in middle-aged or older adults with metabolic syndrome?
The metabolic syndrome group had less cortical thickness in medial temporal lobe regions. Cortical thickness differences were most pronounced in the left entorhinal cortex. Cortical thickness mediated the association between risk factor burden and memory in middle age. Differences in middle age and older adults contribute to an understanding of these relationships.