- 作者：Tetyana Chaychenko ; tatyana.chaychenko@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cardiovascular risk ; Metabolic syndrome ; Metabolically healthy obese ; Adolescents
- 刊名：Polish Annals of Medicine
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：23
- 期：2
- 页码：87-91
- 全文大小：285 K
Aim
This study is designed to determine the risk related cardiovascular changes in metabolically healthy obese adolescents.
Material and methods
208 obese adolescents were grouped as metabolically healthy and metabolically unhealthy by International Diabetes Federation (IDF) criteria for pediatric metabolic syndrome. We analyzed the basic metabolic parameters, left ventricular geometry and function, 24-hours blood pressure monitoring and carotid intima-media thickness. Control group consisted of 23 lean healthy subjects.
Results and discussion
69% of obese adolescents could be considered as metabolically healthy by pediatric IDF criteria. BMI in metabolically unhealthy was greater vs. metabolically healthy (P = 0.019) as well as dyslipidemia and dysglicemia. Cardiovascular parameters were deteriorated in all obese vs. lean healthy (myocardial hypertrophy and dysfunction, thickening of carotid vessels and systolic hypertension). It established low sensitivity (0.28) and low negative predictive value (0.29) of metabolic syndrome criteria to screen obesity associated cardiovascular problems.
Conclusions
Prognostic capability of pediatric metabolic syndrome criteria is pretty low due to its sensitivity. Therefore obese adolescents not met diagnostic level for metabolic syndrome by IDF criteria could be falsely excluded from the cardiovascular risk group. Thus, it is not possible to assert an existence of absolutely healthy metabolic profile in obese and more sensitive markers are necessary for the metabolically healthy obesity identification.