A palladium(II) complex: Synthesis, structure, characterization, electrochemical behavior, thermal aspects, BVS calculation and antimicrobial activity

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• 作者：Chiranjan Biswas^a ; Miaoli Zhu^b ; Liping Lu^b ; Sudipta Kaity^c ; Mousumi Das^c ; Amalesh Samanta^c ; ^{asamanta61@yahoo.co.in} ; Jnan Prakash Naskar^a ; ^{jpnaskar@rediffmail.com}
• 关键词：Oxime ; Palladium ; Structure ; BVS ; Redox ; Cytotoxicity
• 刊名：Polyhedron
• 出版年：2013
• 出版时间：12 June, 2013
• 年：2013
• 卷：56
• 期：Complete
• 页码：211-220
• 全文大小：1282 K

文摘

The reaction of equimolar proportions of Na₂[PdCl₄] and 1-(4-methylimidazol-5-yl) phenylhydrazonopropane-2-one oxime (LH), a 1:1 Schiff-base condensate of 1-hydrazono-1-phenyl-propan-2-one oxime (1) and 4-methylimidazole-5-carboxaldehyde, in methanol gives rise to [Pd(L)(Cl)] (2) in a satisfactory yield. The title monomeric palladium(II) complex, 2, has been characterized by C, H and N microanalyses, ¹H and ¹³C NMR, FAB-MS, FT-IR, UV-Vis spectra, molar electric conductivity measurements and room temperature magnetic susceptibility measurements. The X-ray crystal structures of 1 and 2 have been determined. The structure of 1, a precursor of the ligand (LH), shows that the methyl and phenyl groups are in an ¡®anti¡¯ disposition. Compound 1 crystallizes in the monoclinic space group P2₁ with a = 6.9503(5), b = 6.4535(3), c = 10.1631(6) ?, V = 455.04(5) ?³ and Z = 2. The structure of 2 reveals that it is a distorted square-planar palladium(II) compound. The palladium center is in an ¡®N₃Cl¡¯ coordination chromophore. Complex 2 crystallizes in the tetragonal space group I4₁/a with a = 22.5744(3), b = 22.5744(3), c = 13.2967(2) ?, V = 6776.05(16) ?³ and Z = 16. The thermal and electrochemical aspects of 2 have been studied. Electrochemical studies in DMF show a Pd(II) to Pd(III) oxidation at 0.573 V, along with a reduction of Pd(II) to Pd(I) at ?0.757 V versus Ag/AgCl. A Bond-Valence Sum (BVS) model calculation was performed to assign the oxidation state of the palladium center in 2. The in vitro antimicrobial activity of 2 was tested against both Gram positive and Gram negative bacteria. Complex 2 exhibits satisfactory bacteriostatic activity.