Specific Myosins Control Actin Organization, Cell Morphology, and Migration in Prostate Cancer Cells
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- 作者：Katarzyna A. Makowska1 ; Ruth E. Hughes1 ; Kathryn J. White1 ; Claire M. Wells2 ; claire.wells@kcl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Michelle Peckham1 ; m.peckham@leeds.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：15 December 2015
- 年：2015
- 卷：13
- 期：10
- 页码：2118-2125
- 全文大小：3608 K
文摘
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Myo1b, Myo9b, Myo10, and Myo18a are highly expressed in metastatic prostate cancer
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Knockdown of individual myosins distinctly affects the cytoskeleton and cell migration
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Myosins act in concert to directly influence actin organization and cell migration
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Misregulation of myosin expression may drive the metastatic phenotype