DLK1-DIO3 microRNA cluster has different expression between OCSCs and OCCs (CD44 −/CD133 −). Low miR-134-3p in OCSCs correlates with RAB27a overexpression. We confirmed RAB27a mRNA a novel target of miR-134-3p. Overexpression for miR-134-3p inhibits OCSCs in vitro. MiR-134-3p transfection decreases OCSCs xenograft tumor growth.