The cytokine-serum amyloid A-chemokine network
详细信息 查看全文
- 作者：Mieke De Bucka ; mieke.debuck@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Mieke Gouwya ; mieke.gouwy@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Ji Ming Wangb ; wangji@mail.nih.gov" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Jacques Van Snickc ; d ; jacques.vansnick@bru.licr.org" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Paul Proosta ; paul.proost@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Sofie Struyfa ; sofie.struyf@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Jo Van Dammea ; jo.vandamme@rega.kuleuven.be" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：SAA ; FPR2 ; Chemotaxis ; Cytokines ; TLR2
- 刊名：Cytokine & Growth Factor Reviews
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：55-69
- 全文大小：1223 K
文摘
Cytokines are potent inducers of serum amyloid A (SAA) in hepatocytes.
SAA induces several cytokines and chemokines, mediating its biological functions.
SAA induces chemokines via TLR2 whereas it directly chemoattracts leukocytes via FPR2.
SAA synergizes with induced chemokines to enhance leukocyte migration.
A cytokine-SAA-chemokine cascade is established during inflammation