Ganoderma atrum polysaccharide evokes antitumor activity via cAMP-PKA mediated apoptotic pathway and down-regulation of Ca2+/PKC signal pathway
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- 作者：Shenshen Zhang ; Shaoping Nie ; spnie@ncu.edu.cn" class="auth_mail ; Danfei Huang ; Jianqin Huang ; Yanling Feng ; Mingyong Xie ; myxie@ncu.edu.cn" class="auth_mail
- 关键词：BSA ; bovine serum albumin ; BW ; body weight ; CRBC ; chicken red blood cells ; M桅 ; peritoneal macrophages ; PKA ; protein kinase A ; PKC ; protein kinase C ; PBS ; phosphate-buffered saline ; PSG-1 ; Ganoderma atrum polysaccharide ; TBS ; Tris-buffered saline
- 刊名：Food and Chemical Toxicology
- 出版年：June 2014
- 年：2014
- 卷：68
- 期：Complete
- 页码：239-246
- 全文大小：1021 K
文摘
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PSG-1 inhibited tumor growth and resulted in tumor apoptosis.
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PSG-1 caused a marked increase in cAMP and PKA activities and the PKA protein level.
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PSG-1 decreased cGMP, PKC activities, PKC protein expression and intracellular [Ca2+]i.
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PSG-1 improved the immune system function in tumor-bearing mice.
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PSG-1 has potential as a novel therapeutic agent for carcinoma patients.