文摘
α4β2∗ nAChRs stimulate IPSCs in FS interneurons, in layer V of the mouse PFC (Fr2). In P16–P63 mice, nicotine increased both IPSC and mIPSC frequencies. GABAergic terminals adjacent to PV+ cells expressed α4 nAChR. The percentage of FS cells with somatic α4β2∗ currents decreased with age. Hence, nAChRs may be able to induce local circuit disinhibition in Fr2 PFC.