Aspirin increases mitochondrial fatty acid oxidation

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• 作者：Radha Uppala^a ; Brianne Dudiak^a ; Megan E. Beck^a ; Sivakama S. Bharathi^a ; Yuxun Zhang^a ; Donna B. Stolz^b ; Eric S. Goetzman^a ; ^{Eric.goetzman@chp.edu}
• 关键词：Aspirin ; Fatty acid oxidation ; Mitochondria ; Peroxisomes ; Lysine acetylation ; SIRT3
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：8 January 2017
• 年：2017
• 卷：482
• 期：2
• 页码：346-351
• 全文大小：1080 K
• 卷排序：482

文摘

Aspirin increases mitochondrial—but inhibits peroxisomal—fatty acid oxidation. Aspirin acetylates mitochondrial proteins including fatty acid oxidation enzymes. SIRT3 does not influence the effect of aspirin on fatty acid oxidation. Increased fatty acid oxidation is likely due to altered mitochondrial morphology and respiration.