Strehler-Mildvan correlation is a degenerate manifold of Gompertz fit

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• 作者：Andrei E. Tarkhov^a ; ^b ; ^at@gero.com ; Leonid I. Menshikov^a ; ^c ; Peter O. Fedichev^a ; ^d
• 关键词：Aging parameters ; Gompertz law ; Gompertz-Makeham law ; Strehler-Mildvan correlation ; Fitting parameters degeneracy ; Biostatistics
• 刊名：Journal of Theoretical Biology
• 出版年：2017
• 出版时间：7 March 2017
• 年：2017
• 卷：416
• 期：Complete
• 页码：180-189
• 全文大小：831 K
• 卷排序：416

文摘

Strehler-Mildvan correlation is a degenerate manifold of Gompertz fit, coinciding with a narrow stripe of iso-average lifespan curves. As far as Gompertz law adequately describes mortality, the linear Strehler-Mildvan correlation is observed only in experiments with a modest change in lifespan and breaks down for dramatic lifespan changes. Gompertz fit applied to high-dimensional mortality changes might lead to abnormal behavior of Strehler-Mildvan correlation, such as its breakdowns. The average lifespan is the only stable feature in experiments with low-quality survival curves. An analytical derivation of the degeneracy manifold of Gompertz fit (i.e. Strehler-Mildvan correlation) is presented.