Characterization of molecular properties and regulatory pathways of CrustinPm1 and CrustinPm7 from the black tiger shrimp Penaeus monodon

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• 作者：Sopacha Arayamethakorn^a ; Premruethai Supungul^a ; ^b ; Anchalee Tassanakajon^a ; Kuakarun Krusong^a ; ^{Kuakarun.K@chula.ac.th}
• 关键词：Antimicrobial peptides ; Crustin ; Imd pathway ; Penaeus monodon ; Toll pathway
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：18-29
• 全文大小：1664 K
• 卷排序：67

文摘

CrustinPm1 and crustinPm7 bound to phosphatidic acid (PA) with high affinity and positive cooperativity. It is possible that crustins gain antimicrobial activity through targeting with PA, a lipid signaling messenger. CrustinPm1 was mediated through the Toll signaling pathway, while crustinPm7 was regulated through both the Toll and Imd pathways.