Halofuginone alleviates acute viral myocarditis in suckling BALB/c mice by inhibiting TGF-β1
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- 作者：Xiao-Hua Suna ; 1 ; Jia Fub ; 1 ; Da-Qing Sunc ; daqingsuncd@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Halofuginone ; Inflammatory cytokines ; TGF-β1 ; Th17 cells ; Viral myocarditis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：29 April 2016
- 年：2016
- 卷：473
- 期：2
- 页码：558-564
- 全文大小：1576 K
文摘
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Halofuginone (HF) increases the survival of suckling BALB/c mice infected with acute CVB3.
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HF reduces the expression of Th17 cell markers (IL-17 and IL-23) and the number of CD4+ IL17+ cells.
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Pro-inflammatory cytokines levels associated with myocarditis were reduced by HF in CVB3-treated suckling mice.
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HF alleviates VMC via inhibition of TGF-β1-mediated NF-κB p65/TNF-α pathway.