• 作者：Brian E. Engdahl^a ; ^b ; ^c ; ^d ; Lisa M. James^a ; ^d ; ^e ; Ryan D. Miller^a ; Arthur C. Leuthold^a ; ^b ; Scott M. Lewis^a ; ^f ; Adam F. Carpenter^a ; ^f ; Apostolos P. Georgopoulos^a ; ^b ; ^d ; ^e ; ^f ; ^{omega@umn.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Gulf War Illness (GWI) ; Magnetoencephalography ; Veterans ; Cerebellum ; Brain areas
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：12
• 期：Complete
• 页码：127-132
• 全文大小：755 K

•

This is the first study of brain mechanisms in Gulf War Illness using magnetoencephalography.

•

Substantial differences in brain synchronicity were found in veterans with Gulf War Illness compared to control Gulf War veterans.

•

These differences involved mainly the cerebellum and frontal cortex.

Gulf War Illness is a debilitating disorder of unknown etiology that has affected a substantial number of veterans who served in the 1990–91 Gulf War. A prominent feature of the disease is the presence of neurological, cognitive and mood disorders. Here we assessed dynamic brain function in veterans suffering from Gulf War Illness (in the absence of mental illness) using magnetoencephalography, a high-fidelity method that measures brain activity. We found neural miscommunication in Gulf War Illness (as compared to control participants) entered mainly on the cerebellum and frontal cortex. These results document dynamic brain anomalies in Gulf War Illness and pave the way for further investigations to elucidate the mechanisms leading to those anomalies.