Lewis acid-induced reaction of homophthalic anhydride with imines: a convenient synthesis of trans-isoquinolonic acids

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• 作者：Niefang ; Yu ; Bourel ; Line ; Deprez ; Benoit ; Gesquiere ; Jean-Claude
• 刊名：Tetrahedron Letters
• 出版年：1998
• 出版时间：February 19, 1998
• 年：1998
• 卷：39
• 期：8
• 页码：829-832
• 全文大小：212 K

文摘

Cycloaddition of imines with homophthalic anhydride in the presence of BF₃ leads to the trans isomers of isoquinolonic acids with a high stereoselectivity and avoids the formation of homophtalic amides. This catalyst extends the scope of the reaction to imines which did not react under previously described conditions.