Reactions of salicylaldehydes with alkyl cyanoacetates on the surface of solid catalysts: syntheses of 4H-chromene derivatives

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• 作者：Yu ; Niefang ; Aramini ; James M. ; Germann ; Markus W. ; Huang ; Ziwei
• 关键词：4H-chromene ; cyclization ; Bcl-Z protein ; apoptosis ; anti-cancer agents
• 刊名：Tetrahedron Letters
• 出版年：2000
• 出版时间：September, 2000
• 年：2000
• 卷：41
• 期：36
• 页码：6993-6996
• 全文大小：131 K

文摘

Substituted 4H-chromene derivatives are a new class of compounds that bind Bcl-2 protein and induce apoptosis in tumor cells. Here we report an efficient synthetic method for the preparation of these compounds from salicylaldehyde derivatives and alkyl cyanoacetates under solid-phase catalysis.