Central histaminergic transmission modulates the ethanol induced anxiolysis in mice
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- 作者：Lokesh Verma ; Nishant S. Jain ; nishant.s.jain@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：EPM ; Anxiety ; Ethanol ; Histamine ; l-Histidine ; Histamine receptors
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：313
- 期：Complete
- 页码：38-52
- 全文大小：2898 K
文摘
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Biphasic role of endogenous histamine in the ethanol induced anxiolysis is proposed.
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Low dose of histamine attenuates while high dose enhances the ethanol induced anxiolysis.
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Histamine H1 receptor stimulation counteracts the ethanol induced anxiolysis.
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Histamine H2 receptor stimulation potentiates the ethanol induced anxiolysis.