O2-Me-dT and O2-POB-dT are replication blocking and highly mutagenic lesions in human cells
Both O2-Me-dT and O2-POB-dT induce T → A as the major type of mutations in human cells.
Pols η, ζ and Rev1 play important roles in the TLS of O2-Me-dT and O2-POB-dT.
Pol ζ is a key enzyme for mutagenesis induced by O2-POB-dT.