刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:5 February 2017
年:2017
卷:483
期:2
页码:823-828
全文大小:1095 K
卷排序:483
文摘
Dimerization of NLRP3 pyrin domain does not lead to IL-1β activation. Trimerization of NLRP3 pyrin domain with foldon induces robust IL-1β activation. Trimerization induced IL-1β activation depends on caspase-1. Activation of trimeric NLRP3 pyrin domain proceeds in the absence of ASC specks.