Relationship between activin A level and infarct size in patients with acute myocardial infarction undergoing successful primary coronary intervention

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• 作者：Toru Miyoshi ; Satoshi Hirohata ; Tadahisa Uesugi ; Minoru Hirota ; Hiromichi Ohnishi ; Kunio Nogami ; Kunihiko Hatanaka ; Hiroko Ogawa ; Shinichi Usui ; Shozo Kusachi
• 关键词：Coronary artery disease ; Inflammation ; Diagnosis ; Immunoassay
• 刊名：Clinica Chimica Acta
• 出版年：2009
• 出版时间：March 2009
• 年：2009
• 卷：401
• 期：1-2
• 页码：3-7
• 全文大小：359 K

文摘

Background

Activin A, a member of the transforming growth factor-β cytokine family, has been suggested to have a role in inflammation. We examined the serum level of activin A in patients with acute myocardial infarction (AMI) undergoing successful primary percutaneous coronary intervention (PCI).

Methods

The subjects were 30 AMI patients, 20 stable angina pectoris (AP) patients and 20 normal subjects. The serum levels of activin A in AMI patients were measured before PCI and on days 1, 2, 7, and 14.

Results

Activin A levels before PCI in AMI patients (557 ± 255 pg/ml) showed a significantly higher value than those in AP patients (364 ± 159 pg/ml) and control subjects (316 ± 144 pg/ml). Increased serum activin A level before PCI was decreased on day 2, and then gradually re-elevated on days 7 and 14. The serum activin A level before PCI was correlated with log-transformed peak creatine kinase (CK) as a surrogate of infarct size (r = 0.48, p = 0.008). Stepwise multiple regression analysis demonstrated that the serum activin A level before PCI was an independent predictor of peak CK.

Conclusions

The serum activin A level, increased in AMI, was positively correlated with peak CK and CK-MB levels which are measures of infarction size.