Clinical significance of tissue polypeptide antigen in serum of acute nonlymphocytic leukemia
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- 作者：Sadamori ; Naoki ; Mine ; Mariko ; Kawachi ; Takako ; Hayashibara ; Toshihisa ; Itoyama ; Takahiro ; et. al.
- 关键词：Acute nonlymphocytic leukemia ; tissue polypeptide antigen ; clinical indicator
- 刊名：Leukemia Research
- 出版年：1995
- 出版时间：June, 1995
- 年：1995
- 卷：19
- 期：6
- 页码：407-409
- 全文大小：216 K
文摘
Tissue polypeptide antigen (TPA) in serum was measured at diagnosis in 27 patients with acute nonlymphocytic leukemia (ANLL) (1 FAB M0, 1 M1, 10 M2, 7 M3, 5 M4, 1 M5, 1 M6 and 1 MU). Statistical analysis disclosed a close correlation of TPA level with age (P < 0.01), hemoglobin level (P < 0.05), therapeutic response (P < 0.01) and the length of survival after the initial diagnosis (P < 0.02). A significant difference in TPA level was present between patients with complete remission and those with poor response. To our knowledge, this is the first report to prove a correlation of TPA level with therapeutic response and the length of survival in ANLL.