Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer

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• 作者：Alba Cristobal¹ ; ² ; Henk W.P. van den Toorn¹ ; ² ; Marc van de Wetering³ ; Hans Clevers³ ; ⁴ ; ^{h.clevers@hubrecht.eu} ; Albert J.R. Heck¹ ; ² ; ^{a.j.r.heck@uu.nl} ; Shabaz Mohammed¹ ; ² ; ⁵ ; ⁶ ; ⁷ ; ^{shabaz.mohammed@chem.ox.ac.uk}
• 关键词：proteomics ; organoids ; mass spectrometry ; colorectal cancer
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：263-274
• 全文大小：3345 K
• 卷排序：18

文摘

Deep proteomic profiling of human colon organoids Common colorectal cancer characteristics were present in all the tumor samples Patient-specific features can be identified that correlate with clinical diagnosis Organoids have the potential to be an excellent model to aid precision treatment