Osteopontin directly modulates cytokine expression of primary microglia and increases their survival
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- 作者：Monika Rabensteina ; Sabine Ulrike Vaya ; Lea Jessica Flitscha ; Gereon Rudolf Finka ; b ; Michael Schroetera ; b ; Maria Adele Ruegera ; b ; adele.rueger@uk-koeln.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Focal cerebral ischemia ; Regeneration ; Neural stem cells ; Neuroprotection ; Neuroinflammation
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：299
- 期：Complete
- 页码：130-138
- 全文大小：1009 K
文摘
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Osteopontin (OPN) enhances microglia survival under stress conditions (serum-free medium)
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OPN dose-dependently abrogates LPS-induced release of nitric oxide and pro-inflammatory cytokines
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OPN exerts anti-inflammatory functions in a moderate inflammatory environment, but does not counteract severe inflammation
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OPN modulates microglia function by shifting their inflammatory profile towards a neutral phenotype