Leptin and Osteopontin are upregulated in NASH and associated with NASH fibrosis
Osteopontin is leptin-regulated and this occurs via the PI3K/Akt signaling pathway
Osteopontin knockdown and neutralization abrogates leptin-mediated fibrogenesis in vitro
OPN neutralization represses diet-induced NASH fibrosis
OPN is a key effector of leptin-mediated fibrogenesis
These data confirm that OPN is an attractive therapeutic target for NASH fibrosis