文摘
Aurone 1 inhibits TNFα, IL-1β, and IL-8 expression in LPS-stimulated THP-1 cells. p65 translocation and NF-κB-dependent transcription is blocked by aurone 1 in macrophages. The mechanism involves inhibition of IKKβ phosphorylation and IκBα degradation. Aurone 1 has no significant effect on LPS-induced MAPK phosphorylation. Aurone 1 suppresses iNOS expression and NO production in RAW264.7 macrophages.