Parasites Dampen Dendritic Cell Activation to Ensure Their Survival

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• 作者：Esther von Stebut¹ ; ^{vonstebu@uni-mainz.de}
• 刊名：Trends in Parasitology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：33
• 期：2
• 页码：78-80
• 全文大小：570 K
• 卷排序：33

文摘

Dendritic cells (DCs) are critical for induction of protective immunity against Leishmania major. However, DC activation occurs only several weeks after parasite transmission. Parasites synthesize a macrophage-inducible C-type lectin (Mincle) ligand. Engagement of Mincle by the parasite ligand dampens DC activation, thus delaying induction of interferon-γ-producing T cells responsible for parasite eradication.