Apoptosis on hepatoma cells but not on primary hepatocytes by histone deacetylase inhibitors valproate and ITF2357
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- 作者：Armeanu ; Sorin ; Pathil ; Anita ; Venturelli ; Sascha ; Mascagni ; Paolo ; Weiss ; Thomas S. ; Gö ; ttlicher ; Martin ; et. al.
- 关键词：Hepatocellular carcinoma ; Histone code ; Cancer ; Programmed cell death ; Bcl-2 proteins ; Hepatotoxicity ; HAT ; histone acetyltransferase ; HCC ; hepatocellular carcinoma ; HDAC ; histone deacetylase ; HDAC-I ; HDAC-inhibitor ; PHH ; primary human hepatocytes ; SAHA
- 刊名：Journal of Hepatology
- 出版年：2005
- 出版时间：February, 2005
- 年：2005
- 卷：42
- 期：2
- 页码：210-217
- 全文大小：372 K
文摘
Due to a particular resistance against conventional chemotherapeutics, palliative treatment of hepatocellular carcinomas (HCC) is highly ineffective. Recent demonstration of both proliferation-inhibition and apoptosis of hepatoma cells by a histone deacetylase inhibitor (HDAC-I) treatment opens up a promising new approach. However, little is known about tumor cell death mechanisms and HDAC-I influences on healthy hepatocytes.