Effects of anticipated neonatal surgical intervention on maternal milk cytokine production

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• 作者：Rebecca M. Rentea^a ; ^{rrentea@cmh.edu} ; Amy J. Wagner^b ; David M. Gourlay^b ; Melissa Christensen^b ; Jennifer L. Liedel^c
• 关键词：Cytokine ; Inflammation ; Cardiac surgery ; Necrotizing enterocolitis ; Il-10 ; Il-23
• 刊名：Journal of Pediatric Surgery
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：52
• 期：1
• 页码：45-49
• 全文大小：458 K
• 卷排序：52

文摘

Maternal stress on neonatal outcomes of infants admitted to the NICU is incompletely understood. We previously demonstrated breast milk derived cytokines remain biologically active in the neonatal intestine. We hypothesized that the need for neonatal surgical intervention would be stimulus leading to maternal cytokine production thus affecting neonatal outcome.MethodsDiscarded expressed breast milk (EBM) in the first 3 weeks following delivery was analyzed for IL-23 and IL-10 by ELISA. Variables analyzed included: the need for a pediatric surgical procedure, the need for cardiac surgical procedure, no surgical interventions, and survival. All values are expressed as mean ± SEM. Statistical analysis utilized Kruskal and Mann–Whitney test.ResultsEBM from mothers whose infants required any surgical procedure (n = 19) revealed significant elevation in IL-10 but not IL-23 compared to nonsurgical EBM (n = 18). Subdivided by procedure type, there was no difference between those undergoing a cardiac (n = 9) versus pediatric surgical (n = 10) procedure in both IL-10 and IL-23. Mothers whose infants requiring surgical intervention or whose infants did not survive in the first 3 weeks of life had elevation of IL-10.ConclusionResults suggest maternal stress impacts the cytokine profile of breast milk.Level of evidenceLevel III.