Metal ion induced autoimmunity

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• 作者：Griem ; Peter ; Gleichmann ; Ernst
• 关键词：AnolA&mdash ; antinucleolar autoantibodies ; APC&mdash ; antigen-presenting cell ; BN&mdash ; Brown Norway ; ConA&mdash ; Concanavalin A ; IFN&mdash ; interferon ; IL&mdash ; interleukin ; mAB&mdash ; monoclonal antibody ; NO&mdash ; nitric oxide ; RNase&mdash ; ribonuclease A ; TC
• 刊名：Current Opinion in Immunology
• 出版年：1995
• 出版时间：December, 1995
• 年：1995
• 卷：7
• 期：6
• 页码：831-838
• 全文大小：780 K

文摘

Metal-induced autoimmunity is a well established but poorly understood phenomenon. Recent work has begun to elucidate the molecular interactions of metal ions with immune cells and self-proteins. Metal-induced presentation of cryptic self-peptides emerges as a possible mechnism for activation of ‘metal-specific’ T cells, challenging the hypothesis of a random polyclonal activation of T and B cells by metals. A preferential T-helper cell type 2 response is involved in metal ion induced systemic autoimmune disease.