Phloretin attenuates LPS-induced acute lung injury in mice via modulation of the NF-κB and MAPK pathways
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- 作者：Wen-Chung Huanga ; b ; 1 ; Ching-Long Laic ; 1 ; Yuan-Ting Liangd ; Hui-Chih Hungd ; Hui-Chia Liud ; Chian-Jiun Lioub ; c ; ccliu@mail.cgust.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：Acute lung injury ; Cytokine ; Lipopolysaccharide ; NF-κB ; Phloretin
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：98-105
- 全文大小：1276 K
文摘
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Phloretin suppressed neutrophil infiltration in a murine model of acute lung injury
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Phloretin decreased gene expression of proinflammatory cytokines and chemokines
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Phloretin inhibited both the NF-κB and MAPK pathways in lung tissue.
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Phloretin induced expression of the cytoprotective antioxidant, HO-1.