Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis
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- 作者：Lei Yin ; Kevin Shengyang Yu1 ; Kun Lu ; Xiaozhong Yu ; yuxz@uga.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Benzyl butyl phthalate ; Adipogenesis ; High Content Cellomics analysis (HCA) ; Gene expression ; Metabolomic analysis
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：32
- 期：Complete
- 页码：297-309
- 全文大小：2593 K
文摘
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High Content analysis showed BBP induced a dose-dependent lipid accumulation.
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BBP promoted adipogenesis through the induction of C/EBPα and PPARγ.
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BBP dynamically activated adipogenic gene: AdipoQ, Adipsin, FABP4, LPL and FASN.
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A metabolomic analysis identified disturbed metabolic pathways induced by BBP.