Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration
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- 作者：Xiao Yan1 ; 2 ; Heather A. Himburg1 ; Katherine Pohl1 ; Mamle Quarmyne1 ; Evelyn Tran1 ; Yurun Zhang1 ; 3 ; Tiancheng Fang1 ; 2 ; Jenny Kan1 ; Nelson J. Chao4 ; Liman Zhao1 ; Phuong L. Doan4 ; John P. Chute1 ; 5 ; 6 ; 7 ; jchute@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：hematopoietic stem cells ; imprinted gene ; adaptor protein ; self-renewal ; regeneration
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：1 November 2016
- 年：2016
- 卷：17
- 期：6
- 页码：1584-1594
- 全文大小：3019 K
文摘
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Grb10, an imprinted gene, is upregulated in regenerating hematopoietic stem cells
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Grb10 deletion promotes hematopoietic stem cell self-renewal following transplantation
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Grb10 deletion increases hematopoietic stem cell regeneration following irradiation
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Hematopoietic stem cell regeneration is mediated via mTORC1 in Grb10-deficient mice