Poliovirus Sabin1-derived CTL vaccine vector RPS-CTP is proposed.
RPS-CTP vector contains cytoplasmic transduction peptide (CTP).
HIV-1 p24-expressing recombinant poliovirus (rec-PV) was produced.
Rec-PV efficiently induced p24-specific CTL in PVR-Tg mice vaccinated orally.
Vaccinated mice were resistant to challenge with p24-expressing vaccinia virus.