TNFAIP3, a negative regulator of the TLR signaling pathway, is a potential predictive biomarker of response to antidepressant treatment in major depressive disorder
文摘
The gene expression profiles of negative regulators of the TLR signaling were low in major depressive disorder. TNFAIP3 expression was inversely associated with severity of depression. Fluoxetine, an antidepressant, directly increased TNFAIP3 gene expression in monocytes and microglia cell lines. TNFAIP3 predicted response of antidepressants treatment.