Characterisation of matrix vesicles in skeletal and soft tissue mineralisation
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- 作者：L. Cui ; Cui.Lin@roslin.ed.ac.uk" class="auth_mail" title="E-mail the corresponding author ; D.A. Houston ; C. Farquharson ; V.E. MacRae
- 关键词：AB ; Apoptotic body ; ADP ; Adenosine diphosphate ; Anx ; Annexin ; ASARM ; Acidic serine- and aspartate-rich motif ; ATP ; Adenosine triphosphate ; BMP ; Bone morphogenetic protein ; CK ; Choline kinase ; CKD ; Chronic kidney disease ; ECM ; Extracellular matrix ; GPI ; Glycosylphosphatidylinositol ; GRP ; Gla-rich protein ; HA ; Hydroxyapatite ; JNK ; c-Jun N-terminal kinase ; LPS ; Lysophosphatidylserine ; MEPE ; Matrix extracellular phosphoglycoprotein ; MGP ; Matrix gla protein ; miRNA ; MicroRNA ; MV ; Matrix vesicle ; NPP1
- 刊名：Bone
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：87
- 期：Complete
- 页码：147-158
- 全文大小：770 K
文摘
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Several mechanisms have been proposed for the nucleation of minerals in matrix vesicles during skeletogenesis.
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Matrix vesicles have been found to be involved in the pathogenesis of vascular mineralisation.
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The protein composition of matrix vesicles derived from skeletal tissues and soft tissues share many similarities.
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Mineralisation mediators could be targeted for therapeutic strategies against vascular mineralisation and bone diseases.