Mutant p53 proteins alter cancer cell secretome and tumour microenvironment: Involvement in cancer invasion and metastasis
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- 作者：Marco Cordania ; Raffaella Pacchianaa ; Giovanna Buteraa ; Gabriella D'Orazib ; Aldo Scarpac ; Massimo Donadellia ; massimo.donadelli@univr.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mutant p53 ; Cancer ; Secretome ; Microenvironment ; Cytokines
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：376
- 期：2
- 页码：303-309
- 全文大小：1597 K
文摘
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Mutp53 contributes to extracellular matrix remodelling.
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Mutp53 induces the secretion of pro-inflammatory, immunomodulatory cytokines.
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Mutp53 stimulates secretion of lactate and induces extracellular acidification.
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Mutp53 regulates the crosstalk between cancer and stromal cells.