Multiple Origins of Virus Persistence during Natural Control of HIV Infection
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- 作者：Eli A. Boritz1 ; Samuel Darko1 ; Luke Swaszek1 ; Gideon Wolf1 ; David Wells2 ; Xiaolin Wu2 ; Amy R. Henry1 ; Farida Laboune1 ; Jianfei Hu1 ; David Ambrozak3 ; Marybeth S. Hughes4 ; Rebecca Hoh5 ; Joseph P. Casazza3 ; Alexander Vostal3 ; Daniel Bunis1 ; Krystelle Nganou-Makamdop1 ; James S. Lee1 ; Stephen A. Migueles6 ; Richard A. Koup3 ; Mark Connors6 ; Susan Moir6 ; Timothy Schacker8 ; Frank Maldarelli7 ; Stephen H. Hughes7 ; Steven G. Deeks5 ; Daniel C. Douek1 ; ddouek@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：11 August 2016
- 年：2016
- 卷：166
- 期：4
- 页码：1004-1015
- 全文大小：1592 K
文摘
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In HIV controllers, both TFH and non-TFH lymph node CD4 T cells contain HIV
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Lymph node viruses in both TFH and non-TFH have attributes of active replication
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Rare, recently infected cells that produce virus upon stimulation circulate in blood
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Archival proviruses predominant in clonally expanded blood cells can be inducible