文摘
We investigated dopamine release in striatum, midbrain and pallidum after injection of human corticotropin hormone (i.v.) in humans. Two positron emission tomography scans with the dopamine D2/3 receptor agonist [11C]-(+)-PHNO were conducted: one after placebo and one after iv corticotropin hormone. We report that iv corticotropin hormone led to a detectable decrease in overall [11C]-(+)-PHNO binding, interpreted as increased dopamine release.