Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast
The MAPK Slt2 of budding yeast forms a complex with Grx3/Grx4 monothiol glutaredoxins. Clusters iron-sulphur and Cysteine residues play a role in Slt2/Grx3/Grx4 interaction. Slt2/Grx3/Grx4 complex is required for the response to oxidative stress. Slt2 dimer formation increases upon oxidative treatment and requires iron. Grx4 regulates Slt2 activation in response to oxidative stress.