Two proprotein convertase subtilisin/kexin type 9 (PCSK9) paralogs from the tropical sea cucumber (Stichopus monotuberculatus): Molecular characterization and inducible expression with immune challenge
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- 作者：Chunhua Rena ; b ; rosemary166@sina.com" class="auth_mail" title="E-mail the corresponding author ; Ting Chena ; b ; chan1010@scsio.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Xiao Jianga ; jiangxiao4367@126.com" class="auth_mail" title="E-mail the corresponding author ; Hongyan Sunc ; 274109225@qq.com" class="auth_mail" title="E-mail the corresponding author ; Jing Qiana ; qianjing198722@126.com" class="auth_mail" title="E-mail the corresponding author ; Chaoqun Hua ; b ; hucq@scsio.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Yanhong Wanga ; yhwang@scsio.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Proprotein convertase subtilisin/kexin type 9 ; Stichopus monotuberculatus ; cDNA ; Gene structure ; Innate immune defense
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：56
- 期：Complete
- 页码：255-262
- 全文大小：2474 K
文摘
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The cDNA and gene sequences of two PCSK9s are identified from a sea cucumber.
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StmPCSK9-1 is a secreted protein while StmPCK9-2 is a cytoplasm protein.
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Only StmPCSK9-1 mRNA may be stimulated by LPS and inhibited by poly (I:C) in coelomocytes.
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StmPCSK9-1 may play critical roles in the innate immune defense of sea cucumber.