Nrf2/ARE is the potential pathway to protect Sprague-Dawley rats against oxidative stress induced by quinocetone

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• 作者：Miao Yu ; Mengjing Xu ; Yang Liu ; Wei Yang ; Ying Rong ; Ping Yao ; Hong Yan ; Di Wang ; Liegang Liu
• 关键词：QCT ; quinocetone ; ROS ; reactive oxygen species ; SD rats ; Sprague&ndash ; Dawley rats ; QdNOs ; quinoxaline-1 ; 4-dioxides family ; GST ; glutathione S-transferase ; HO-1 ; heme oxygenase-1 ; GPx ; glutathione peroxidase ; GCL ; glutamate cysteine ligase ; PRX I ; peroxir
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2013
• 出版时间：August, 2013
• 年：2013
• 卷：66
• 期：3
• 页码：279-285
• 全文大小：2216 K

文摘

3-methyl-2-quinoxalin benzenevinylketo-1, 4-dioxide (Quinocetone, QCT) is a newly used veterinary drug which has been proven to promote feed efficiency and growth of animals; however, its potential toxicity can¡¯t be ignored. Therefore, the present study was aimed to investigate the nephrotoxicity of QCT and the oxidative stress induced by it. Sprague-Dawley rats (SD rats) were randomly divided into four groups with doses of 2400, 800, 50 and 0 mg/kg/day with administration of QCT for 4 weeks. Results proved that QCT could induce nephrotoxicity and this phenomenon had dose dependent manner. Simultaneously, this phenomenon was accompanied by intracellular reactive oxygen species (ROS) accumulation, enhanced lipid peroxidation and inhibited antioxidant system, i.e. glutathione S-transferase (GST), glutathione peroxidase (GPx) and glutathione reductase (GSH). Additionally, the higher expression of Nrf2 in QCT treated groups illustrated that QCT-induced oxidative stress would be partly mitigated by the induction of phase II detoxifying enzymes via increasing Nrf2 expression.